The Science Behind the Relief
Best known for its soothing and skin-healing properties, Aloe vera also plays a remarkable role beneath the surface — helping active ingredients penetrate through the skin. Rich in natural polysaccharides, enzymes, and saponins, Aloe vera gently softens the skin barrier and increases the transdermal delivery of key active ingredients, improving bioavailability and efficacy in topical formulations.
Known for its deep roots in traditional medicine, Arctium lappa (burdock root) has long been used to calm inflammation and purify the body. Modern science supports its powerful anti-inflammatory and antioxidant effects — driven by natural compounds like arctigenin and arctiin, which help inhibit key inflammatory mediators and protect tissues from oxidative stress.
Clinical research shows that burdock can reduce inflammatory markers and support joint comfort, while laboratory studies confirm its ability to modulate cytokines such as IL-6, TNF-α, and COX-2. Together, these findings highlight burdock’s role as a potent natural ally for easing inflammation, promoting recovery, and supporting long-term joint health.
Extracted from chili peppers, capsaicin delivers targeted relief by de-sensitising pain receptors and depleting Substance P — a key neurotransmitter that carries pain signals. When applied topically, it produces a gentle warming sensation that helps to interrupt pain transmission and improve circulation to affected muscles and joints.
Medical research confirms the efficacy of capsaicin creams for osteoarthritis, chronic low back pain, and neuropathic pain. Repeated application over several weeks leads to meaningful reductions in pain intensity and stiffness, improved mobility, and enhanced quality of life — making it one of the most studied and effective natural ingredients for topical pain relief.
Glucosamine, commonly sourced from shellfish, has been researched for many years for its role in supporting knee osteoarthritis (OA). Scientists have also investigated its potential structure-modifying effects, a term used to describe ingredients that may help protect joint cartilage and reduce the progression of structural changes over time. Numerous reviews show benefits for both pain and everyday function.
Clinical and experimental data consistently support Arnica montana as a natural, topical anti-inflammatory for pain, swelling, and muscle recovery. Its effects are mediated through reduced cytokine activity and oxidative stress, making it a powerful natural adjunct to conventional pain management.